Recombination and positive selection contribute to evolution of Listeria monocytogenes inlA
نویسندگان
چکیده
منابع مشابه
Recombination and positive selection contribute to evolution of Listeria monocytogenes inlA.
The surface molecule InlA interacts with E-cadherin to promote invasion of Listeria monocytogenes into selected host cells. DNA sequencing of inlA for 40 L. monocytogenes isolates revealed 107 synonymous and 45 nonsynonymous substitutions. A frameshift mutation in a homopolymeric tract encoding part of the InlA signal peptide was identified in three lineage II isolates, which also showed reduce...
متن کاملThe inlA gene required for cell invasion is conserved and specific to Listeria monocytogenes.
The Gram-positive bacterium Listeria monocytogenes can actively induce its own uptake by epithelial cells and fibroblasts through a surface-exposed 80 kDa protein, internalin (InIA), encoded by inIA. We studied the distribution and the DNA polymorphism of inIA sequences in a wide variety of wild strains of L. monocytogenes as compared to other Listeria species. This was done by PCR-amplifying i...
متن کاملThe inlA gene of Listeria monocytogenes LO28 harbors a nonsense mutation resulting in release of internalin.
Internalin is a surface protein that mediates entry of Listeria monocytogenes EGD into epithelial cells expressing the cell adhesion molecule human E-cadherin or its chicken homolog, L-CAM, which act as receptors for internalin. After observing that entry of L. monocytogenes LO28 into S180 fibroblasts, in contrast to that of EGD, did not increase after transfection with L-CAM, we examined both ...
متن کاملA New Perspective on Listeria monocytogenes Evolution
Listeria monocytogenes is a model organism for cellular microbiology and host-pathogen interaction studies and an important food-borne pathogen widespread in the environment, thus representing an attractive model to study the evolution of virulence. The phylogenetic structure of L. monocytogenes was determined by sequencing internal portions of seven housekeeping genes (3,288 nucleotides) in 36...
متن کاملDETERMINATION OF DOMINANT SEROVARS OF LISTERIA MONOCYTOGENES
Serovars of Lisreria l1Iollocyrogelles were determined. Sera of aborted samples (200) were collected from different hospitals in Tehran and were tested serologically by immunofluorescent antibody methods (IF tests). 137 positive sera were identified. Positive sera were tested against 12 serovars of Listeria l1Iollocytogelles separately. Titers of antibody in patients' sera for all serovars ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Microbiology
سال: 2007
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.2007/007310-0